8OY2

Human cyclin-dependent kinase 2 in complex with inhibitor HB-29260

8OY2 の概要

• エントリーDOI: 10.2210/pdb8oy2/pdb
• 分子名称: Cyclin-dependent kinase 2, (1S,2S,11aS)-1-methoxy-1,4,7,10-tetramethyl-2,9-bis(oxidanyl)-2,11a-dihydrobenzo[b][1,4]benzodioxepine-3,6-dione, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: inhibitor, kinase, cell cycle
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34545.06

構造登録者

Kordes, S.,Harvey, C.J.B. (登録日: 2023-05-03, 公開日: 2023-11-29, 最終更新日: 2023-12-06)

• 主引用文献: Dunbar, K.L.,Perlatti, B.,Liu, N.,Cornelius, A.,Mummau, D.,Chiang, Y.M.,Hon, L.,Nimavat, M.,Pallas, J.,Kordes, S.,Ng, H.L.,Harvey, C.J.B.; Resistance gene-guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases.; Proc.Natl.Acad.Sci.USA, 120:e2310522120-e2310522120, 2023; PubMed: 37983497; DOI: 10.1073/pnas.2310522120

実験手法

X-RAY DIFFRACTION (2.618 Å)