8OX3

Structure of the murine LYVE-1 (lymphatic vessel endothelial receptor-1) hyaluronan binding domain bound with octasaccharide hyaluronan.

Summary for 8OX3

• Entry DOI: 10.2210/pdb8ox3/pdb
• Descriptor: Lymphatic vessel endothelial hyaluronic acid receptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: hyaluronan binding, cell migration, lymphatic system, cell adhesion
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 36653.84

Authors

Ni, T.,Bannerji, N.,Jackson, D.J.,Gilbert, R.J.C. (deposition date: 2023-04-30, release date: 2025-02-12)

• Primary citation: Bano, F.,Bannerji, S.,Ni, T.,Green, D.E.,DeAngelis, P.L.,Paci, E.,Lepsik, M.,Gilbert, R.J.C.,Richter, R.P.,Jackson, D.J.; A novel sliding interaction with hyaluronan underlies the mode of action of LYVE-1, the receptor for leucocyte entry and trafficking in the lymphatics; To be published,

Experimental method

X-RAY DIFFRACTION (1.05 Å)