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8OWB

Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP and 2-(5-bromo-1-(4-hydroxyphenyl)-1H-indol-3-yl)-2-oxoacetic acid

Summary for 8OWB
Entry DOI10.2210/pdb8owb/pdb
DescriptorCoenzyme A biosynthesis bifunctional protein CoaBC, CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, ... (5 entities in total)
Functional Keywordscoab, coabc, fragment inhibitor, ligase
Biological sourceMycolicibacterium smegmatis MC2 155
Total number of polymer chains4
Total formula weight101909.21
Authors
Mendes, V.,Blundell, T.L. (deposition date: 2023-04-27, release date: 2024-05-08)
Primary citationHess, J.,Mendes, V.,Evans, J.C.,Trapero, A.,Marchetti, C.,Blaszczyk, M.,Bryant, O.,Spry, C.,Coyne, A.G.,Boshoff, H.I.M.,Barry, C.E.,Mizrahi, V.,Blundell, T.L.,Abell, C.
Development of new inhibitors against M. tuberculosis CoaBC using a fragment based approach.
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

226707

數據於2024-10-30公開中

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