8OVZ

Crystal structure of D1228V c-MET bound by compound 16

Summary for 8OVZ

• Entry DOI: 10.2210/pdb8ovz/pdb
• Descriptor: Hepatocyte growth factor receptor, IODIDE ION, 1-[(1S)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl]-5-(1H-indazol-7-yl)pyrimidine-2,4-dione, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, cancer research, drug discovery, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 72860.74

Authors

Collie, G.W. (deposition date: 2023-04-26, release date: 2023-07-05, Last modification date: 2023-09-20)

• Primary citation: Michaelides, I.N.,Collie, G.W.,Borjesson, U.,Vasalou, C.,Alkhatib, O.,Barlind, L.,Cheung, T.,Dale, I.L.,Embrey, K.J.,Hennessy, E.J.,Khurana, P.,Koh, C.M.,Lamb, M.L.,Liu, J.,Moss, T.A.,O'Neill, D.J.,Phillips, C.,Shaw, J.,Snijder, A.,Storer, R.I.,Stubbs, C.J.,Han, F.,Li, C.,Qiao, J.,Sun, D.Q.,Wang, J.,Wang, P.,Yang, W.; Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.; J.Med.Chem., 66:8782-8807, 2023; PubMed: 37343272; DOI: 10.1021/acs.jmedchem.3c00401

Experimental method

X-RAY DIFFRACTION (2.206 Å)