8OVZ

Crystal structure of D1228V c-MET bound by compound 16

8OVZ の概要

• エントリーDOI: 10.2210/pdb8ovz/pdb
• 分子名称: Hepatocyte growth factor receptor, IODIDE ION, 1-[(1S)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl]-5-(1H-indazol-7-yl)pyrimidine-2,4-dione, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, cancer research, drug discovery, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72860.74

構造登録者

Collie, G.W. (登録日: 2023-04-26, 公開日: 2023-07-05, 最終更新日: 2023-09-20)

• 主引用文献: Michaelides, I.N.,Collie, G.W.,Borjesson, U.,Vasalou, C.,Alkhatib, O.,Barlind, L.,Cheung, T.,Dale, I.L.,Embrey, K.J.,Hennessy, E.J.,Khurana, P.,Koh, C.M.,Lamb, M.L.,Liu, J.,Moss, T.A.,O'Neill, D.J.,Phillips, C.,Shaw, J.,Snijder, A.,Storer, R.I.,Stubbs, C.J.,Han, F.,Li, C.,Qiao, J.,Sun, D.Q.,Wang, J.,Wang, P.,Yang, W.; Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.; J.Med.Chem., 66:8782-8807, 2023; PubMed: 37343272; DOI: 10.1021/acs.jmedchem.3c00401

実験手法

X-RAY DIFFRACTION (2.206 Å)