8OU6

Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11c

Summary for 8OU6

Entry DOI	10.2210/pdb8ou6/pdb
Descriptor	Cereblon isoform 4, ZINC ION, 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methyl-benzamide, ... (5 entities in total)
Functional Keywords	cereblon, protac, e3, molecular glue, signaling protein
Biological source	Magnetospirillum gryphiswaldense MSR-1 v2
Total number of polymer chains	3
Total formula weight	36343.87
Authors	Heim, C.,Bischof, L.,Hartmann, M.D. (deposition date: 2023-04-21, release date: 2023-11-15, Last modification date: 2023-11-22)
Primary citation	Steinebach, C.,Bricelj, A.,Murgai, A.,Sosic, I.,Bischof, L.,Ng, Y.L.D.,Heim, C.,Maiwald, S.,Proj, M.,Voget, R.,Feller, F.,Kosmrlj, J.,Sapozhnikova, V.,Schmidt, A.,Zuleeg, M.R.,Lemnitzer, P.,Mertins, P.,Hansen, F.K.,Gutschow, M.,Kronke, J.,Hartmann, M.D. Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J.Med.Chem., 66:14513-14543, 2023 Cited by PubMed: 37902300 DOI: 10.1021/acs.jmedchem.3c00851 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation