8OSL
Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement)
Summary for 8OSL
Entry DOI | 10.2210/pdb8osl/pdb |
EMDB information | 17160 |
Descriptor | Histone H3.1, Histone H4, Histone H2A type 1-B/E, ... (8 entities in total) |
Functional Keywords | e-box, transcription factor, circadian clock, gene regulation |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 14 |
Total formula weight | 377793.55 |
Authors | Michael, A.K.,Stoos, L.,Kempf, G.,Cavadini, S.,Thoma, N. (deposition date: 2023-04-19, release date: 2023-05-24, Last modification date: 2024-07-24) |
Primary citation | Michael, A.K.,Stoos, L.,Crosby, P.,Eggers, N.,Nie, X.Y.,Makasheva, K.,Minnich, M.,Healy, K.L.,Weiss, J.,Kempf, G.,Cavadini, S.,Kater, L.,Seebacher, J.,Vecchia, L.,Chakraborty, D.,Isbel, L.,Grand, R.S.,Andersch, F.,Fribourgh, J.L.,Schubeler, D.,Zuber, J.,Liu, A.C.,Becker, P.B.,Fierz, B.,Partch, C.L.,Menet, J.S.,Thoma, N.H. Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619:385-393, 2023 Cited by PubMed: 37407816DOI: 10.1038/s41586-023-06282-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.9 Å) |
Structure validation
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