8OSJ

Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1)

8OSJ の概要

• エントリーDOI: 10.2210/pdb8osj/pdb
• EMDBエントリー: 17155
• 分子名称: Histone H3.1, Histone H4, Histone H2A type 1-B/E, ... (8 entities in total)
• 機能のキーワード: e-box, transcription factor, circadian clock, gene regulation
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 293910.36

構造登録者

Michael, A.K.,Stoos, L.,Kempf, G.,Cavadini, S.,Thoma, N.H. (登録日: 2023-04-19, 公開日: 2023-05-24, 最終更新日: 2024-07-24)

• 主引用文献: Michael, A.K.,Stoos, L.,Crosby, P.,Eggers, N.,Nie, X.Y.,Makasheva, K.,Minnich, M.,Healy, K.L.,Weiss, J.,Kempf, G.,Cavadini, S.,Kater, L.,Seebacher, J.,Vecchia, L.,Chakraborty, D.,Isbel, L.,Grand, R.S.,Andersch, F.,Fribourgh, J.L.,Schubeler, D.,Zuber, J.,Liu, A.C.,Becker, P.B.,Fierz, B.,Partch, C.L.,Menet, J.S.,Thoma, N.H.; Cooperation between bHLH transcription factors and histones for DNA access.; Nature, 619:385-393, 2023; PubMed: 37407816; DOI: 10.1038/s41586-023-06282-3

実験手法

ELECTRON MICROSCOPY (6.2 Å)