8OS2

Structure of the human LYVE-1 (lymphatic vessel endothelial receptor-1) hyaluronan binding domain in an unliganded state

Summary for 8OS2

• Entry DOI: 10.2210/pdb8os2/pdb
• Related: 8ORX
• Descriptor: Lymphatic vessel endothelial hyaluronic acid receptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (4 entities in total)
• Functional Keywords: hyaluronan binding, cell migration, lymphatic system, cell adhesion
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 16729.32

Authors

Ni, T.,Bannerji, S.,Jackson, D.J.,Gilbert, R.J.C. (deposition date: 2023-04-17, release date: 2024-07-31)

• Primary citation: Bano, F.,Bannerji, S.,Ni, T.,Green, D.E.,DeAngelis, P.L.,Paci, E.,Lepsik, M.,Jackson, D.J.,Gilbert, R.J.C.; A novel sliding interaction with hyaluronan underlies the mode of action of LYVE-1, the receptor for leucocyte entry and trafficking in the lymphatics; To be published,

Experimental method

X-RAY DIFFRACTION (1.64 Å)