8OQP

Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-76

8OQP の概要

• エントリーDOI: 10.2210/pdb8oqp/pdb
• 分子名称: 3-hydroxyacyl-CoA dehydrogenase, Putative acyltransferase Rv0859, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: fatty acid beta oxidation complex, mycobacterium tuberculosis, tfe, fragment screening, substrate channeling, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis H37Rv; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 246442.96

構造登録者

Dalwani, S.,Wierenga, R.K.,Venkatesan, R. (登録日: 2023-04-12, 公開日: 2024-01-24, 最終更新日: 2024-08-14)

• 主引用文献: Dalwani, S.,Metz, A.,Huschmann, F.U.,Weiss, M.S.,Wierenga, R.K.,Venkatesan, R.; Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them.; Acta Crystallogr D Struct Biol, 80:605-619, 2024; PubMed: 39012716; DOI: 10.1107/S2059798324006557

実験手法