8OPW
Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Caffeine (Fragment-B-51)
Summary for 8OPW
| Entry DOI | 10.2210/pdb8opw/pdb |
| Descriptor | 3-hydroxyacyl-CoA dehydrogenase, Putative acyltransferase Rv0859, SULFATE ION, ... (6 entities in total) |
| Functional Keywords | fatty acid beta oxidation complex, mycobacterium tuberculosis, tfe, fragment screening, substrate channeling, oxidoreductase |
| Biological source | Mycobacterium tuberculosis H37Rv More |
| Total number of polymer chains | 4 |
| Total formula weight | 244463.00 |
| Authors | |
| Primary citation | Dalwani, S.,Metz, A.,Huschmann, F.U.,Weiss, M.S.,Wierenga, R.K.,Venkatesan, R. Crystallographic fragment binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate channeling path between them Biorxiv, 2024 Cited by DOI: 10.1101/2024.01.11.575214PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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