8OOJ

Crystal structure of dCK C4S-S74E mutant in complex with EdC and UDP

8OOJ の概要

• エントリーDOI: 10.2210/pdb8ooj/pdb
• 分子名称: Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, 4-azanyl-1-[(2~{R},4~{S},5~{R})-5-ethynyl-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]pyrimidin-2-one, ... (4 entities in total)
• 機能のキーワード: nucleoside kinase, phosphorylation, complex, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 133428.11

構造登録者

Saez-Ayala, M.,Rebuffet, E.,Betzi, S.,Morelli, X. (登録日: 2023-04-05, 公開日: 2023-12-20, 最終更新日: 2024-05-15)

• 主引用文献: Calbert, M.L.,Chandramouly, G.,Adams, C.M.,Saez-Ayala, M.,Kent, T.,Tyagi, M.,Ayyadevara, V.S.S.A.,Wang, Y.,Krais, J.J.,Gordon, J.,Atkins, J.,Toma, M.M.,Betzi, S.,Boghossian, A.S.,Rees, M.G.,Ronan, M.M.,Roth, J.A.,Goldman, A.R.,Gorman, N.,Mitra, R.,Childers, W.E.,Grana, X.,Skorski, T.,Johnson, N.,Hurtz, C.,Morelli, X.,Eischen, C.M.,Pomerantz, R.T.; 4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.; Mol.Cancer Ther., 23:683-699, 2024; PubMed: 38064712; DOI: 10.1158/1535-7163.MCT-23-0487

実験手法

X-RAY DIFFRACTION (2.1 Å)