8ONI

Human insulin in complex with the analytical antibody S1 Fab

8ONI の概要

• エントリーDOI: 10.2210/pdb8oni/pdb
• 分子名称: Heavy chain of analytical antibody S1 Fab, Light chain of analytical antibody S1 Fab, Insulin A chain, ... (6 entities in total)
• 機能のキーワード: insulin, analytical antibody, s1, hormone
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 107679.75

構造登録者

Johansson, E. (登録日: 2023-04-03, 公開日: 2024-04-10, 最終更新日: 2025-10-22)

主引用文献

Christoffersen, S.,Baumann, K.,Millner, A.H.,Toft-Hansen, H.,Johansson, E.,Thorlaksen, C.,Skov, P.S.
IgE clonality and aggregation of insulin affect IgE-mediated activation of sensitized basophils.
J Allergy Clin Immunol Glob, 4:100502-100502, 2025

PubMed Abstract: Skin prick testing and specific IgE determination do not discriminate between sensitization and clinically relevant insulin allergic reactions, whereas the basophil histamine release assay has proven useful in identifying clinically relevant food and drug allergic reactions.

PubMed: 40583959
DOI: 10.1016/j.jacig.2025.100502

実験手法

X-RAY DIFFRACTION (2.3 Å)