8OK0
Crystal structure of human NQO1 in complex with the inhibitor PMSF
Summary for 8OK0
Entry DOI | 10.2210/pdb8ok0/pdb |
Descriptor | NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, phenylmethanesulfonic acid, ... (6 entities in total) |
Functional Keywords | human nqo1, flavoenzyme, cancer, inhibitors, pmsf, flavoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 127801.66 |
Authors | Martin-Garcia, J.M.,Grieco, A.,Ruiz-Fresneda, M.A. (deposition date: 2023-03-26, release date: 2023-11-01, Last modification date: 2023-11-22) |
Primary citation | Grieco, A.,Ruiz-Fresneda, M.A.,Gomez-Mulas, A.,Pacheco-Garcia, J.L.,Quereda-Moraleda, I.,Pey, A.L.,Martin-Garcia, J.M. Structural dynamics at the active site of the cancer-associated flavoenzyme NQO1 probed by chemical modification with PMSF. Febs Lett., 597:2687-2698, 2023 Cited by PubMed: 37726177DOI: 10.1002/1873-3468.14738 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report![Download](https://newweb-cs.pages.dev/newweb/media/icons/dl.png)
![Download](https://newweb-cs.pages.dev/newweb/media/icons/dl.png)