8OJM
Galectin-3 in complex with 2,6-anhydro-3-deoxy-3-S-(beta-D-galactopyranosyl)-3-thio-D-glycero-D-galacto-heptonamide
Summary for 8OJM
Entry DOI | 10.2210/pdb8ojm/pdb |
Descriptor | Galectin-3, (2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxane-2-carboxamide, 1-thio-beta-D-galactopyranose, ... (5 entities in total) |
Functional Keywords | sugar binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 16177.37 |
Authors | Tsagkarakou, A.S.,Leonidas, D.D. (deposition date: 2023-03-24, release date: 2023-09-13, Last modification date: 2023-09-20) |
Primary citation | Lazar, L.,Tsagkarakou, A.S.,Stravodimos, G.,Kontopidis, G.,Leffler, H.,Nilsson, U.J.,Somsak, L.,Leonidas, D.D. Strong Binding of C -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds. J.Med.Chem., 66:12420-12431, 2023 Cited by PubMed: 37658813DOI: 10.1021/acs.jmedchem.3c00882 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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