8OFI
Ivabradine bound to HCN4 channel
Summary for 8OFI
| Entry DOI | 10.2210/pdb8ofi/pdb |
| EMDB information | 16860 |
| Descriptor | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Ivabradine (2 entities in total) |
| Functional Keywords | hcn channels, ivabradine, ion transport, membrane protein, drug, hearth, hcn4 |
| Biological source | Oryctolagus cuniculus (rabbit) |
| Total number of polymer chains | 4 |
| Total formula weight | 394559.49 |
| Authors | Saponaro, A.,Chaves-Sanjuan, A.,Sharifzadeh, A.S.,Clarke, O.B.,Marabelli, C.,Bolognesi, M.,Thiel, G.,Moroni, A. (deposition date: 2023-03-15, release date: 2024-08-14) |
| Primary citation | Saponaro, A.,Krumbach, J.H.,Chaves-Sanjuan, A.,Sharifzadeh, A.S.,Porro, A.,Castelli, R.,Hamacher, K.,Bolognesi, M.,DiFrancesco, D.,Clarke, O.B.,Thiel, G.,Moroni, A. Structural determinants of ivabradine block of the open pore of HCN4. Proc.Natl.Acad.Sci.USA, 121:e2402259121-e2402259121, 2024 Cited by PubMed: 38917012DOI: 10.1073/pnas.2402259121 PDB entries with the same primary citation |
| Experimental method |
Structure validation
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