8OF2

Trypanosoma brucei pteridine reductase 1 (TbPTR1) in complex with 2,4,6 triamminopyrimidine (TAP)

8OF2 の概要

• エントリーDOI: 10.2210/pdb8of2/pdb
• 分子名称: Pteridine reductase, PYRIMIDINE-2,4,6-TRIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: trypanosoma brucei, pteridine reductase, ptr1, tbptr1, triamminopyrimidine, oxidoreductase
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126341.53

構造登録者

Tassone, G.,Landi, G.,Mangani, S.,Pozzi, C. (登録日: 2023-03-13, 公開日: 2023-12-13)

• 主引用文献: Linciano, P.,Pozzi, C.,Tassone, G.,Landi, G.,Mangani, S.,Santucci, M.,Luciani, R.,Ferrari, S.,Santarem, N.,Tagliazucchi, L.,Cordeiro-da-Silva, A.,Tonelli, M.,Tondi, D.,Bertarini, L.,Gul, S.,Witt, G.,Moraes, C.B.,Costantino, L.,Costi, M.P.; The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.; Eur.J.Med.Chem., 264:115946-115946, 2023; PubMed: 38043491; DOI: 10.1016/j.ejmech.2023.115946

実験手法

X-RAY DIFFRACTION (1.48 Å)