8KI3

Structure of the human ATP synthase bound to bedaquiline (composite)

Summary for 8KI3

• Entry DOI: 10.2210/pdb8ki3/pdb
• EMDB information: 37251
• Descriptor: ATP synthase subunit alpha, mitochondrial, ATP synthase subunit d, mitochondrial, ATP synthase subunit a, ... (21 entities in total)
• Functional Keywords: atp synthase, human, cryo-em, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 28
• Total formula weight: 591925.43

Authors

Lai, Y.,Zhang, Y.,Gong, H. (deposition date: 2023-08-22, release date: 2024-05-01, Last modification date: 2024-08-21)

• Primary citation: Zhang, Y.,Lai, Y.,Zhou, S.,Ran, T.,Zhang, Y.,Zhao, Z.,Feng, Z.,Yu, L.,Xu, J.,Shi, K.,Wang, J.,Pang, Y.,Li, L.,Chen, H.,Guddat, L.W.,Gao, Y.,Liu, F.,Rao, Z.,Gong, H.; Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587.; Nature, 631:409-414, 2024; PubMed: 38961288; DOI: 10.1038/s41586-024-07605-8

Experimental method

ELECTRON MICROSCOPY (2.89 Å)