8K78

Crystal structure of cMET kinase domain bound by TPX-0022

Summary for 8K78

• Entry DOI: 10.2210/pdb8k78/pdb
• Descriptor: Hepatocyte growth factor receptor, Elzovantinib (3 entities in total)
• Functional Keywords: cmet, tpx-0022, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35251.74

Authors

Qu, L.Z.,Chen, Y.H. (deposition date: 2023-07-26, release date: 2024-07-31)

• Primary citation: Qu, L.,Lin, H.,Dai, S.,Guo, M.,Chen, X.,Jiang, L.,Zhang, H.,Li, M.,Liang, X.,Chen, Z.,Wei, H.,Chen, Y.; Structural insight into the macrocyclic inhibitor TPX-0022 of c-Met and c-Src.; Comput Struct Biotechnol J, 21:5712-5718, 2023; PubMed: 38074469; DOI: 10.1016/j.csbj.2023.11.028

Experimental method

X-RAY DIFFRACTION (2.67 Å)