8K77
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam
This is a non-PDB format compatible entry.
Summary for 8K77
Entry DOI | 10.2210/pdb8k77/pdb |
EMDB information | 36935 |
Descriptor | Synaptic vesicle glycoprotein 2A, Botulinum neurotoxin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | synapse, epilepsy, antiepileptic drug, botulinum neurotoxin, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 134455.45 |
Authors | Yamagata, A. (deposition date: 2023-07-26, release date: 2024-05-01, Last modification date: 2024-05-08) |
Primary citation | Yamagata, A.,Ito, K.,Suzuki, T.,Dohmae, N.,Terada, T.,Shirouzu, M. Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15:3027-3027, 2024 Cited by PubMed: 38637505DOI: 10.1038/s41467-024-47322-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.11 Å) |
Structure validation
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