8K4F

DHODH in complex with compound A0

Summary for 8K4F

Entry DOI	10.2210/pdb8k4f/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, SULFATE ION, TETRAETHYLENE GLYCOL, ... (9 entities in total)
Functional Keywords	inhibitor, complex, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41711.94
Authors	Jian, L.,Sun, Q. (deposition date: 2023-07-18, release date: 2024-05-29)
Primary citation	Zhou, X.,Gou, K.,Xu, J.,Jian, L.,Luo, Y.,Li, C.,Guan, X.,Qiu, J.,Zou, J.,Zhang, Y.,Zhong, X.,Zeng, T.,Zhou, Y.,Xiao, Y.,Yang, X.,Chen, W.,Gao, P.,Liu, C.,Zhou, Y.,Tao, L.,Liu, X.,Cen, X.,Chen, Q.,Sun, Q.,Luo, Y.,Zhao, Y. Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease. J.Med.Chem., 66:14755-14786, 2023 Cited by PubMed: 37870434 DOI: 10.1021/acs.jmedchem.3c01365 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation