8K2A

Cryo-EM structure of the human 55S mitoribosome with Tigecycline

This is a non-PDB format compatible entry.

Summary for 8K2A

• Entry DOI: 10.2210/pdb8k2a/pdb
• EMDB information: 36836
• Descriptor: 16S rRNA, Large ribosomal subunit protein uL14m, Large ribosomal subunit protein uL15m, ... (87 entities in total)
• Functional Keywords: 55s mitoribosome, tigecycline, antibiotic, ribosome
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 83
• Total formula weight: 2889198.22

Authors

Li, X.,Wang, M.,Cheng, J. (deposition date: 2023-07-12, release date: 2024-07-10)

• Primary citation: Li, X.,Wang, M.,Denk, T.,Buschauer, R.,Li, Y.,Beckmann, R.,Cheng, J.; Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.; Nat Commun, 15:5481-5481, 2024; PubMed: 38942792; DOI: 10.1038/s41467-024-49797-7

Experimental method

ELECTRON MICROSCOPY (2.9 Å)