8JZM

The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210

8JZM の概要

• エントリーDOI: 10.2210/pdb8jzm/pdb
• 分子名称: Toll/interleukin-1 receptor domain-containing adapter protein (1 entity in total)
• 機能のキーワード: toll-like receptor (tlr) signalling the cytoplasmic tir (toll/interleukin-1 receptor) domains, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16031.20

構造登録者

Rahaman, M.H.,Jia, X.,Maxwell, M.J.,Mobli, M.,Kobe, B. (登録日: 2023-07-05, 公開日: 2024-05-01)

• 主引用文献: Rahaman, M.H.,Thygesen, S.J.,Maxwell, M.J.,Kim, H.,Mudai, P.,Nanson, J.D.,Jia, X.,Vajjhala, P.R.,Hedger, A.,Vetter, I.,Haselhorst, T.,Robertson, A.A.B.,Dymock, B.,Ve, T.,Mobli, M.,Stacey, K.J.,Kobe, B.; o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.; J Enzyme Inhib Med Chem, 39:2313055-2313055, 2024; PubMed: 38416868; DOI: 10.1080/14756366.2024.2313055

実験手法

SOLUTION NMR