8JVI

Structure of human TRPV4 with antagonist A2

Summary for 8JVI

• Entry DOI: 10.2210/pdb8jvi/pdb
• EMDB information: 36675
• Descriptor: Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone (2 entities in total)
• Functional Keywords: channel, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 516804.70

Authors

Fan, J.,Lei, X. (deposition date: 2023-06-28, release date: 2024-05-08, Last modification date: 2024-07-17)

• Primary citation: Fan, J.,Guo, C.,Liao, D.,Ke, H.,Lei, J.,Xie, W.,Tang, Y.,Tominaga, M.,Huang, Z.,Lei, X.; Structural Pharmacology of TRPV4 Antagonists.; Adv Sci, 11:-, 2024; PubMed: 38659239; DOI: 10.1002/advs.202401583

Experimental method

ELECTRON MICROSCOPY (3.21 Å)