8JUG

Crystal structure of human MMP-7 in complex with inhibitor

8JUG の概要

• エントリーDOI: 10.2210/pdb8jug/pdb
• 分子名称: Matrilysin, Peptide Inhibitor, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: matrilysin, matrin, matrix metalloproteinase-7, pump-1 protease, uterine metalloproteinase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20494.13

構造登録者

Kamitani, M.,Abe-Sato, K.,Oka, Y. (登録日: 2023-06-26, 公開日: 2023-11-01, 最終更新日: 2023-11-22)

• 主引用文献: Abe-Sato, K.,Tabuse, H.,Kanazawa, H.,Kamitani, M.,Endo, M.,Tokura, S.,Wakabayashi, S.,Yahara, T.,Takeda, T.,Hitaka, K.,Gunji, E.,Kojima, N.,Oka, Y.; Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.; J.Med.Chem., 66:14653-14668, 2023; PubMed: 37861435; DOI: 10.1021/acs.jmedchem.3c01166

実験手法

X-RAY DIFFRACTION (1.3 Å)