8JUE

Crystal structure of glutaminase C in complex with compound 11

8JUE の概要

• エントリーDOI: 10.2210/pdb8jue/pdb
• 分子名称: Glutaminase kidney isoform, mitochondrial, 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide (3 entities in total)
• 機能のキーワード: inhibitor, complex, antitumor protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 236070.54

構造登録者

Wang, X.,Hanyu, S.,Tingting, D. (登録日: 2023-06-26, 公開日: 2023-10-11, 最終更新日: 2023-11-01)

• 主引用文献: Sun, H.,Du, T.,Yang, M.,Liu, X.,Xue, X.,Chen, K.,Lang, X.,Chen, X.,Wang, B.,Wang, X.; Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors.; Acs Med.Chem.Lett., 14:1455-1466, 2023; PubMed: 37849538; DOI: 10.1021/acsmedchemlett.3c00375

実験手法

X-RAY DIFFRACTION (2.39 Å)