8JUC

Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening

Summary for 8JUC

Entry DOI	10.2210/pdb8juc/pdb
Descriptor	Ubiquitin-conjugating enzyme E2 T, 7-methyl-2-(trifluoromethyl)-3~{H}-[1,2,4]triazolo[1,5-a]pyridin-5-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	ube2t; ubiquitination; fragment-based drug discovery, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	18171.88
Authors	Anantharajan, J.,Baburajendran, N. (deposition date: 2023-06-26, release date: 2024-02-28)
Primary citation	Loh, Y.Y.,Anantharajan, J.,Huang, Q.,Xu, W.,Fulwood, J.,Ng, H.Q.,Ng, E.Y.,Gea, C.Y.,Choong, M.L.,Tan, Q.W.,Koh, X.,Lim, W.H.,Nacro, K.,Cherian, J.,Baburajendran, N.,Ke, Z.,Kang, C. Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening. Protein Sci., 33:e4904-e4904, 2024 Cited by PubMed: 38358126 DOI: 10.1002/pro.4904 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation