8JUA

Multifunctional cytochrome P450 enzyme IkaD from Streptomyces sp. ZJ306, in complex with epoxyikarugamycin

8JUA の概要

• エントリーDOI: 10.2210/pdb8jua/pdb
• 関連するPDBエントリー: 8JNC 8JNO 8JOO
• 分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, (1Z,3E,5S,7R,8R,10R,11R,12S,13R,15S,16R,17S,19Z,26S)-11-ethyl-2-hydroxy-10-methyl-22,27-diaza-14 oxahexacyclo[24.2.1.05,17.07,16.013,15.08,12]nonacosa-1(2),3,19-triene-21,28,29-trione, ... (5 entities in total)
• 機能のキーワード: c-h functionalization, regioselectivity, chemoselectivity, polycyclic tetramate macrolactam (potem), cytochrome p450 enzyme, oxidoreductase
• 由来する生物種: Streptomyces sp. ZJ306
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98707.34

構造登録者

Zhang, Y.L.,Zhang, L.P.,Zhang, C.S. (登録日: 2023-06-26, 公開日: 2023-11-15, 最終更新日: 2023-12-20)

• 主引用文献: Jiang, P.,Jin, H.,Zhang, G.,Zhang, W.,Liu, W.,Zhu, Y.,Zhang, C.,Zhang, L.; A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates.; Angew.Chem.Int.Ed.Engl., 62:e202310728-e202310728, 2023; PubMed: 37917570; DOI: 10.1002/anie.202310728

実験手法

X-RAY DIFFRACTION (2.00001111553 Å)