8JU3

Mu phage tail fiber

8JU3 の概要

• エントリーDOI: 10.2210/pdb8ju3/pdb
• 分子名称: Tail fiber protein S,Tail fiber protein S' (2 entities in total)
• 機能のキーワード: bacteriophage, viral protein
• 由来する生物種: Escherichia phage Mu; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52697.31

構造登録者

Yamashita, E.,Takeda, S. (登録日: 2023-06-24, 公開日: 2024-02-28, 最終更新日: 2024-09-11)

主引用文献

Mori, Y.,Yamashita, E.,Nakagawa, A.,Matsuzawa, T.,Inagaki, M.,Aiba, Y.,Tanaka, S.,Hatori, S.,Ayami, M.,Takeda, S.
Determination of the three-dimensional structure of bacteriophage Mu(-) tail fiber and its characterization.
Virology, 593:110017-110017, 2024

PubMed Abstract: Bacteriophage Mu is a temperate phage known to infect various species of Enterobacteria, playing a role in bacterial mutation induction and horizontal gene transfer. The phage possesses two types of tail fibers important for host recognition, which enable it to expand its range of hosts. The alternate tail fibers are formed through the action of genes 49-50 or 52-51, allowing the Mu phage to recognize different surfaces of host cells. In a previous study, we presented the X-ray crystal structure of the C-terminal lipopolysaccharide (LPS)-binding domain of gene product (gp) 49, one of the subunits comprising the Mu tail fiber. In this study, we have determined the structure of the alternative tail fiber subunit, gp52, and compared it with other tail fibers. The results revealed that Mu phage employs different structural motifs for two individual tail fibers for recognizing different hosts.

PubMed: 38382161
DOI: 10.1016/j.virol.2024.110017

実験手法

X-RAY DIFFRACTION (2 Å)