8JP1

Crystal structure of AKR1C3 in complex with DFV

Summary for 8JP1

Entry DOI	10.2210/pdb8jp1/pdb
Descriptor	Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE, ... (4 entities in total)
Functional Keywords	aldo-keto reductase 1c3;17beta-hydroxysteroid dehydrogenase type 5; complex;inhibitor;flavanone, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	77954.06
Authors	Zheng, X.H.,Liu, H.,Yao, Z.Q.,Zhang, L.P. (deposition date: 2023-06-10, release date: 2024-04-24)
Primary citation	Liu, H.,Yao, Z.,Sun, M.,Zhang, C.,Huang, Y.Y.,Luo, H.B.,Wu, D.,Zheng, X. Inhibition of AKR1Cs by liquiritigenin and the structural basis. Chem.Biol.Interact., 385:110654-110654, 2023 Cited by PubMed: 37666442 DOI: 10.1016/j.cbi.2023.110654 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation