8JP1

Crystal structure of AKR1C3 in complex with DFV

8JP1 の概要

• エントリーDOI: 10.2210/pdb8jp1/pdb
• 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE, ... (4 entities in total)
• 機能のキーワード: aldo-keto reductase 1c3;17beta-hydroxysteroid dehydrogenase type 5; complex;inhibitor;flavanone, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77954.06

構造登録者

Zheng, X.H.,Liu, H.,Yao, Z.Q.,Zhang, L.P. (登録日: 2023-06-10, 公開日: 2024-04-24)

• 主引用文献: Liu, H.,Yao, Z.,Sun, M.,Zhang, C.,Huang, Y.Y.,Luo, H.B.,Wu, D.,Zheng, X.; Inhibition of AKR1Cs by liquiritigenin and the structural basis.; Chem.Biol.Interact., 385:110654-110654, 2023; PubMed: 37666442; DOI: 10.1016/j.cbi.2023.110654

実験手法

X-RAY DIFFRACTION (2 Å)