8JHK

Cryo-EM structure of the DOCK5/ELMO1 complex, focused on one protomer

Summary for 8JHK

Entry DOI	10.2210/pdb8jhk/pdb
EMDB information	36271
Descriptor	Engulfment and cell motility protein 1, Dedicator of cytokinesis protein 5 (2 entities in total)
Functional Keywords	elmo, dock, gef, gtpase, rho, rac, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	467321.97
Authors	Kukimoto-Niino, M.,Katsura, K.,Ishizuka-Katsura, Y.,Mishima-Tsumagari, C.,Yonemochi, M.,Inoue, M.,Nakagawa, R.,Kaushik, R.,Zhang, K.Y.J.,Shirouzu, M. (deposition date: 2023-05-23, release date: 2024-05-29, Last modification date: 2024-06-26)
Primary citation	Kukimoto-Niino, M.,Katsura, K.,Ishizuka-Katsura, Y.,Mishima-Tsumagari, C.,Yonemochi, M.,Inoue, M.,Nakagawa, R.,Kaushik, R.,Zhang, K.Y.J.,Shirouzu, M. RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state. J.Biol.Chem., :107459-107459, 2024 Cited by PubMed: 38857861 DOI: 10.1016/j.jbc.2024.107459 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.76 Å)

Structure validation