8JGF

CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22

8JGF の概要

• エントリーDOI: 10.2210/pdb8jgf/pdb
• EMDBエントリー: 36232
• 分子名称: Guanine nucleotide-binding protein Gq, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Single-Chain Fragment Variable 16, ... (6 entities in total)
• 機能のキーワード: itch receptor, mas-related gpcrs, mgprx1, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 154904.64

構造登録者

Sun, J.P.,Xu, H.E.,Yang, F.,Liu, Z.M.,Guo, L.L.,Zhang, Y.M.,Fang, G.X.,Tie, L.,Zhuang, Y.M.,Xue, C.Y. (登録日: 2023-05-20, 公開日: 2024-01-10)

• 主引用文献: Guo, L.,Zhang, Y.,Fang, G.,Tie, L.,Zhuang, Y.,Xue, C.,Liu, Q.,Zhang, M.,Zhu, K.,You, C.,Xu, P.,Yuan, Q.,Zhang, C.,Liu, L.,Rong, N.,Peng, S.,Liu, Y.,Wang, C.,Luo, X.,Lv, Z.,Kang, D.,Yu, X.,Zhang, C.,Jiang, Y.,Dong, X.,Zhou, J.,Liu, Z.,Yang, F.,Eric Xu, H.,Sun, J.P.; Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.; Nat Commun, 14:5004-5004, 2023; PubMed: 37591889; DOI: 10.1038/s41467-023-40705-z

実験手法

ELECTRON MICROSCOPY (2.7 Å)