8JED

Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors

8JED の概要

• エントリーDOI: 10.2210/pdb8jed/pdb
• 分子名称: mRNA-capping enzyme regulatory subunit OPG124 (2 entities in total)
• 機能のキーワード: monkeypox virus, n7-methyltransferase e12 subunit, inhibitors, transferase
• 由来する生物種: Monkeypox virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34663.89

構造登録者

Wang, D.,Zhao, R.,Shu, W.,Hu, W.,Wang, M.,Cao, J.,Zhou, X. (登録日: 2023-05-15, 公開日: 2023-12-06)

• 主引用文献: Wang, D.P.,Zhao, R.,Wang, H.F.,Wang, M.Y.,Hu, W.S.,Lin, M.M.,Shu, W.,Sun, Y.J.,Cao, J.M.,Cui, W.,Zhou, X.; Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors.; Int.J.Biol.Macromol., 253:127565-127565, 2023; PubMed: 37866584; DOI: 10.1016/j.ijbiomac.2023.127565

実験手法

X-RAY DIFFRACTION (2.16 Å)