8JBO

Crystal structure of TxGH116 from Thermoanaerobacterium xylanolyticum with isofagomine

Summary for 8JBO

• Entry DOI: 10.2210/pdb8jbo/pdb
• Related: 5BVU 5BX2 5BX3 5BX4 5BX5
• Descriptor: Glucosylceramidase, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: txgh116, beta-glucosidase, acid/base mutant, thermoanaerobacterium xylanolyticum, cellobiose, hydrolase
• Biological source: Thermoanaerobacterium xylanolyticum LX-11
• Total number of polymer chains: 2
• Total formula weight: 185826.81

Authors

Pengthaisong, S.,Ketudat Cairns, J.R. (deposition date: 2023-05-09, release date: 2023-10-11)

• Primary citation: Meelua, W.,Thinkumrob, N.,Saparpakorn, P.,Pengthaisong, S.,Hannongbua, S.,Ketudat Cairns, J.R.,Jitonnom, J.; Structural basis for inhibition of a GH116 beta-glucosidase and its missense mutants by GBA2 inhibitors: Crystallographic and quantum chemical study.; Chem.Biol.Interact., 384:110717-110717, 2023; PubMed: 37726065; DOI: 10.1016/j.cbi.2023.110717

Experimental method

X-RAY DIFFRACTION (2 Å)