8IVX8IVX の概要
| エントリーDOI | 10.2210/pdb8ivx/pdb |
| 分子名称 | aNRP2-14, Heavy chain of antibody 14V4 Fab fragment, Light chain of antibody 14V4 Fab fragment, ... (5 entities in total) |
| 機能のキーワード | complex, antibody, membrane protein |
| 由来する生物種 | Homo sapiens (human) 詳細 |
| タンパク質・核酸の鎖数 | 3 |
| 化学式量合計 | 114544.73 |
| 構造登録者 | |
| 主引用文献 | Xu, Z.,Goel, H.L.,Burkart, C.,Burman, L.,Chong, Y.E.,Barber, A.G.,Geng, Y.,Zhai, L.,Wang, M.,Kumar, A.,Menefee, A.,Polizzi, C.,Eide, L.,Rauch, K.,Rahman, J.,Hamel, K.,Fogassy, Z.,Klopp-Savino, S.,Paz, S.,Zhang, M.,Cubitt, A.,Nangle, L.A.,Mercurio, A.M. Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. Sci Transl Med, 15:eadf1128-eadf1128, 2023 Cited by PubMed Abstract: Although blocking the binding of vascular endothelial growth factor (VEGF) to neuropilin-2 (NRP2) on tumor cells is a potential strategy to treat aggressive carcinomas, a lack of effective reagents that can be used clinically has hampered this potential therapy. Here, we describe the generation of a fully humanized, high-affinity monoclonal antibody (aNRP2-10) that specifically inhibits the binding of VEGF to NRP2, conferring antitumor activity without causing toxicity. Using triple-negative breast cancer as a model, we demonstrated that aNRP2-10 could be used to isolate cancer stem cells (CSCs) from heterogeneous tumor populations and inhibit CSC function and epithelial-to-mesenchymal transition. aNRP2-10 sensitized cell lines, organoids, and xenografts to chemotherapy and inhibited metastasis by promoting the differentiation of CSCs to a state that is more responsive to chemotherapy and less prone to metastasis. These data provide justification for the initiation of clinical trials designed to improve the response of patients with aggressive tumors to chemotherapy using this monoclonal antibody. PubMed: 37134152DOI: 10.1126/scitranslmed.adf1128 主引用文献が同じPDBエントリー |
| 実験手法 | X-RAY DIFFRACTION (1.9 Å) |
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