8IV5
Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 1C4 (local refinement)
Summary for 8IV5
Entry DOI | 10.2210/pdb8iv5/pdb |
EMDB information | 35741 |
Descriptor | Spike protein S1, light chain of 8H12, heavy chain of 8H12, ... (6 entities in total) |
Functional Keywords | sars-cov-2, neutralizing antibody, cryo-em, viral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 5 |
Total formula weight | 73731.36 |
Authors | |
Primary citation | Sun, H.,Deng, T.,Zhang, Y.,Lin, Y.,Jiang, Y.,Jiang, Y.,Huang, Y.,Song, S.,Cui, L.,Li, T.,Xiong, H.,Lan, M.,Liu, L.,Li, Y.,Fang, Q.,Yu, K.,Jiang, W.,Zhou, L.,Que, Y.,Zhang, T.,Yuan, Q.,Cheng, T.,Zhang, Z.,Yu, H.,Zhang, J.,Luo, W.,Li, S.,Zheng, Q.,Gu, Y.,Xia, N. Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD. Protein Cell, 15:121-134, 2024 Cited by PubMed: 37470320DOI: 10.1093/procel/pwad040 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.77 Å) |
Structure validation
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