8IV4

Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 3E2 (local refinement)

8IV4 の概要

• エントリーDOI: 10.2210/pdb8iv4/pdb
• EMDBエントリー: 35740
• 分子名称: light chain of 3E2, heavy chain of 3E2, light chain of 8H12, ... (6 entities in total)
• 機能のキーワード: sars-cov-2, neutralizing antibody, cryo-em, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 72850.50

構造登録者

Sun, H.,Jiang, Y.,Zheng, Q.,Li, S.,Xia, N. (登録日: 2023-03-26, 公開日: 2023-08-16, 最終更新日: 2024-02-14)

• 主引用文献: Sun, H.,Deng, T.,Zhang, Y.,Lin, Y.,Jiang, Y.,Jiang, Y.,Huang, Y.,Song, S.,Cui, L.,Li, T.,Xiong, H.,Lan, M.,Liu, L.,Li, Y.,Fang, Q.,Yu, K.,Jiang, W.,Zhou, L.,Que, Y.,Zhang, T.,Yuan, Q.,Cheng, T.,Zhang, Z.,Yu, H.,Zhang, J.,Luo, W.,Li, S.,Zheng, Q.,Gu, Y.,Xia, N.; Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD.; Protein Cell, 15:121-134, 2024; PubMed: 37470320; DOI: 10.1093/procel/pwad040

実験手法

ELECTRON MICROSCOPY (3.59 Å)