8ITX
Crystal structure of human Galectin-3 in complex with small molecule inhibitor
Summary for 8ITX
Entry DOI | 10.2210/pdb8itx/pdb |
Descriptor | Galectin-3, CHLORIDE ION, 2-[(2S,3R,4S,5R,6R)-2-[2-[2,5-bis(chloranyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-5-oxidanyl-oxan-3-yl]oxyethanoic acid, ... (5 entities in total) |
Functional Keywords | fibrosis, galactose, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 40779.35 |
Authors | |
Primary citation | Swidorski, J.J.,Beno, B.B.,Liu, C.,Yoon, D.,Ghosh, K.,Sale, H.,Shah, D.,Acharya, K.,Yanchunas, J.,Ellsworth, B.,Cheng, D.,Regueiro-Ren, A. Discovery and Exploration of Monosaccharide Linked Dimers to Target Fibrosis To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.12 Å) |
Structure validation
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