8ITL

Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein

8ITL の概要

• エントリーDOI: 10.2210/pdb8itl/pdb
• EMDBエントリー: 35706
• 分子名称: Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
• 機能のキーワード: cryo-electron microscopy; g protein-coupled receptor;splice variant; receptor activation., structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 149953.25

構造登録者

Zhao, F.H.,Hang, K.N.,Zhou, Q.T.,Shao, L.J.,Li, H.,Li, W.Z.,Lin, S.,Dai, A.T.,Cai, X.Q.,Liu, Y.Y.,Xu, Y.N.,Feng, W.B.,Yang, D.H.,Wang, M.W. (登録日: 2023-03-22, 公開日: 2023-10-18)

• 主引用文献: Zhao, F.,Hang, K.,Zhou, Q.,Shao, L.,Li, H.,Li, W.,Lin, S.,Dai, A.,Cai, X.,Liu, Y.,Xu, Y.,Feng, W.,Yang, D.,Wang, M.W.; Molecular basis of signal transduction mediated by the human GIPR splice variants.; Proc.Natl.Acad.Sci.USA, 120:e2306145120-e2306145120, 2023; PubMed: 37792509; DOI: 10.1073/pnas.2306145120

実験手法

ELECTRON MICROSCOPY (3.23 Å)