8ISO

Crystal structure of extended-spectrum class A beta-lactamase, CESS-1

8ISO の概要

• エントリーDOI: 10.2210/pdb8iso/pdb
• 関連するPDBエントリー: 1O7E
• 分子名称: Beta-lactamase, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... (4 entities in total)
• 機能のキーワード: hydrolase, extended-spectrum class a beta-lactamase
• 由来する生物種: Stenotrophomonas sp. KCTC 12332
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29886.65

構造登録者

Jeong, B.G.,Kim, M.Y.,Jeong, C.S.,Do, H.W.,Lee, J.H.,Cha, S.S. (登録日: 2023-03-21, 公開日: 2024-05-15)

主引用文献

Jeong, B.G.,Kim, M.Y.,Jeong, C.S.,Do, H.,Hwang, J.,Lee, J.H.,Cha, S.S.
Characterization of the extended substrate spectrum of the class A beta-lactamase CESS-1 from Stenotrophomonas sp. and structure-based investigation into its substrate preference.
Int J Antimicrob Agents, 63:107171-107171, 2024

PubMed Abstract: Stenotrophomonas spp. intrinsically resistant to many β-lactam antibiotics are found throughout the environment. CESS-1 identified in Stenotrophomonas sp. KCTC 12332 is an uncharacterized class A β-lactamase. The goal of this study was to reveal biochemical and structural characteristics of CESS-1.

PubMed: 38588869
DOI: 10.1016/j.ijantimicag.2024.107171

実験手法

X-RAY DIFFRACTION (1.29 Å)