8IQ6

Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex

Summary for 8IQ6

• Entry DOI: 10.2210/pdb8iq6/pdb
• EMDB information: 35658
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, complex, prostaglandin receptor, agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 133434.36

Authors

Lv, X.,Gao, K.,Nie, J.,Zhang, X.,Zhang, S.,Ren, Y.,Li, Q.,Huang, J.,Liu, L.,Zhang, X.,Sun, X.,Zhang, W.,Liu, X. (deposition date: 2023-03-15, release date: 2024-01-31)

• Primary citation: Lv, X.,Gao, K.,Nie, J.,Zhang, X.,Zhang, S.,Ren, Y.,Sun, X.,Li, Q.,Huang, J.,Liu, L.,Zhang, X.,Zhang, W.,Liu, X.; Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity.; Nat Commun, 14:8136-8136, 2023; PubMed: 38065938; DOI: 10.1038/s41467-023-43922-8

Experimental method

ELECTRON MICROSCOPY (3.4 Å)