8IOC

Cryo-EM structure of the gamma-MSH-bound human melanocortin receptor 3 (MC3R)-Gs complex

8IOC の概要

• エントリーDOI: 10.2210/pdb8ioc/pdb
• EMDBエントリー: 35615
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, HA signal peptide,Melanocortin receptor 3,LgBiT subunit, ... (7 entities in total)
• 機能のキーワード: human melanocortin receptor 3, g protein-coupled receptor, ligand recpgnition, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 165228.84

構造登録者

Feng, W.B.,Zhou, Q.T.,Chen, X.Y.,Dai, A.T.,Cai, X.Q.,Liu, X.,Zhao, F.H.,Chen, Y.,Ye, C.Y.,Xu, Y.N.,Cong, Z.T.,Li, H.,Lin, S. (登録日: 2023-03-10, 公開日: 2023-09-20)

• 主引用文献: Feng, W.,Zhou, Q.,Chen, X.,Dai, A.,Cai, X.,Liu, X.,Zhao, F.,Chen, Y.,Ye, C.,Xu, Y.,Cong, Z.,Li, H.,Lin, S.,Yang, D.,Wang, M.W.; Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.; Cell Discov, 9:81-, 2023; PubMed: 37524700; DOI: 10.1107/S0907444909042073

実験手法

ELECTRON MICROSCOPY (2.86 Å)