8INZ

Cryo-EM structure of human HCN3 channel in apo state

Summary for 8INZ

• Entry DOI: 10.2210/pdb8inz/pdb
• EMDB information: 35602
• Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3, 4-[[(2~{S},4~{a}~{R},6~{S},8~{a}~{S})-6-[(4~{S},5~{R})-4-[(2~{S})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{H}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid (2 entities in total)
• Functional Keywords: human hcn3 channel, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 346542.78

Authors

Yu, B.,Lu, Q.Y.,Li, J.,Zhang, J. (deposition date: 2023-03-10, release date: 2024-04-10, Last modification date: 2024-07-10)

• Primary citation: Yu, B.,Lu, Q.,Li, J.,Cheng, X.,Hu, H.,Li, Y.,Che, T.,Hua, Y.,Jiang, H.,Zhang, Y.,Xian, C.,Yang, T.,Fu, Y.,Chen, Y.,Nan, W.,McCormick, P.J.,Xiong, B.,Duan, J.,Zeng, B.,Li, Y.,Fu, Y.,Zhang, J.; Cryo-EM structure of human HCN3 channel and its regulation by cAMP.; J.Biol.Chem., 300:107288-107288, 2024; PubMed: 38636662; DOI: 10.1016/j.jbc.2024.107288

Experimental method

ELECTRON MICROSCOPY (2.72 Å)