8INR

Cryo-EM structure of the alpha-MSH-bound human melanocortin receptor 5 (MC5R)-Gs complex

8INR の概要

• エントリーDOI: 10.2210/pdb8inr/pdb
• EMDBエントリー: 35601
• 分子名称: HA signal peptide,Melanocortin receptor 5,LgBiT subunit, alpha-melanocyte-stimulating hormone, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
• 機能のキーワード: human melanocortin receptor 5, g protein-coupled receptor, ligand recpgnition, membrane protein
• 由来する生物種: Influenza A virus (A/Victoria/3/1975(H3N2)); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 148555.05

構造登録者

Feng, W.B.,Zhou, Q.T.,Chen, X.Y.,Dai, A.T.,Cai, X.Q.,Liu, X.,Zhao, F.H.,Chen, Y.,Ye, C.Y.,Xu, Y.N.,Cong, Z.T.,Li, H.,Lin, S.,Yang, D.H.,Wang, M.W. (登録日: 2023-03-10, 公開日: 2023-09-20)

• 主引用文献: Feng, W.,Zhou, Q.,Chen, X.,Dai, A.,Cai, X.,Liu, X.,Zhao, F.,Chen, Y.,Ye, C.,Xu, Y.,Cong, Z.,Li, H.,Lin, S.,Yang, D.,Wang, M.W.; Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.; Cell Discov, 9:81-, 2023; PubMed: 37524700; DOI: 10.1107/S0907444909042073

実験手法

ELECTRON MICROSCOPY (2.73 Å)