8IME

Human cGAS catalytic domain bound with baicalin

Summary for 8IME

• Entry DOI: 10.2210/pdb8ime/pdb
• Descriptor: Cyclic GMP-AMP synthase, 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, ZINC ION, ... (4 entities in total)
• Functional Keywords: cgas, inhibitor, baicalin, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86542.08

Authors

Zhao, W.F.,Xu, Y.C. (deposition date: 2023-03-06, release date: 2024-01-03)

• Primary citation: Li, J.,Xiong, M.,Liu, J.,Zhang, F.,Li, M.,Zhao, W.,Xu, Y.; Discovery of novel cGAS inhibitors based on natural flavonoids.; Bioorg.Chem., 140:106802-106802, 2023; PubMed: 37666112; DOI: 10.1016/j.bioorg.2023.106802

Experimental method

X-RAY DIFFRACTION (2.63 Å)