8IM6

Crystal structure of HCoV 229E main protease in complex with PF07304814

Summary for 8IM6

• Entry DOI: 10.2210/pdb8im6/pdb
• Descriptor: 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate (3 entities in total)
• Functional Keywords: viral protein
• Biological source: Human coronavirus 229E
• Total number of polymer chains: 2
• Total formula weight: 66647.45

Authors

Zhou, Y.R.,Zeng, P.,Zhang, J.,Li, J. (deposition date: 2023-03-06, release date: 2024-03-06)

• Primary citation: Zhou, Y.,Wang, W.,Zeng, P.,Feng, J.,Li, D.,Jing, Y.,Zhang, J.,Yin, X.,Li, J.,Ye, H.,Wang, Q.; Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332.; Biochem.Biophys.Res.Commun., 657:16-23, 2023; PubMed: 36965419; DOI: 10.1016/j.bbrc.2023.03.043

Experimental method

X-RAY DIFFRACTION (2.01 Å)