8IM6
Crystal structure of HCoV 229E main protease in complex with PF07304814
Summary for 8IM6
Entry DOI | 10.2210/pdb8im6/pdb |
Descriptor | 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate (3 entities in total) |
Functional Keywords | viral protein |
Biological source | Human coronavirus 229E |
Total number of polymer chains | 2 |
Total formula weight | 66647.45 |
Authors | |
Primary citation | Zhou, Y.,Wang, W.,Zeng, P.,Feng, J.,Li, D.,Jing, Y.,Zhang, J.,Yin, X.,Li, J.,Ye, H.,Wang, Q. Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332. Biochem.Biophys.Res.Commun., 657:16-23, 2023 Cited by PubMed: 36965419DOI: 10.1016/j.bbrc.2023.03.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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