8IL3
Cryo-EM structure of CD38 in complex with FTL004
Summary for 8IL3
Entry DOI | 10.2210/pdb8il3/pdb |
EMDB information | 35526 |
Descriptor | Light chain, Heavy chain, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (3 entities in total) |
Functional Keywords | monoclonal antibody, hydrolase |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 73581.55 |
Authors | |
Primary citation | Zhang, G.,Guo, C.,Wang, Y.,Zhang, X.,Liu, S.,Qu, W.,Chen, C.,Yan, L.,Yang, Z.,Zhang, Z.,Jiang, X.,Chen, X.,Liu, H.,Lai, Q.,Wei, X.,Lu, Y.,Zhao, S.,Deng, H.,Wang, Y.,Yu, L.,Yu, H.,Wu, Y.,Su, Z.,Chen, P.,Ren, Z.,Yu, M.,Qu, F.,Luo, Y.,Gou, L.,Li, Q.,Huang, Y.,Ma, F.,Yang, J. FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma. J Hematol Oncol, 15:177-177, 2022 Cited by PubMed: 36581954DOI: 10.1186/s13045-022-01395-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.86 Å) |
Structure validation
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