8IKH

Cryo-EM structure of human receptor with G proteins

Summary for 8IKH

• Entry DOI: 10.2210/pdb8ikh/pdb
• EMDB information: 35512
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: membrane protein, complex, allosteric modulator
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 151595.20

Authors

Shen, S.Y.,Shao, Z.H. (deposition date: 2023-02-28, release date: 2024-06-05, Last modification date: 2024-07-17)

• Primary citation: Shen, S.,Wu, C.,Lin, G.,Yang, X.,Zhou, Y.,Zhao, C.,Miao, Z.,Tian, X.,Wang, K.,Yang, Z.,Liu, Z.,Guo, N.,Li, Y.,Xia, A.,Zhou, P.,Liu, J.,Yan, W.,Ke, B.,Yang, S.,Shao, Z.; Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1.; Proc.Natl.Acad.Sci.USA, 121:e2321532121-e2321532121, 2024; PubMed: 38830102; DOI: 10.1073/pnas.2321532121

Experimental method

ELECTRON MICROSCOPY (3.3 Å)